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JWH 307 is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB1) and the peripheral cannabinoid (CB2) receptors. The affinities of JWH 250 for both CB1 (Ki = 11 nM) and CB2 (Ki = 33 nM) are comparable to those of the traditional cannabinoid, ?9-tetrahydrocannabinol (?9-THC; Ki = 40.7 and 36.4 nM, respectively).1